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How does Genomics, Proteomics and Bioinformatics help in Target Discovery?

Hi guys,

Like the title say, I would like to know how these helps in Target Discovery. Please be as clear as possible. I feel that the target is discovered based on "theory". For example if you have a heartbeat disorder, you probably want to target the calcium channel. However, I dont see how genomics, proteomics and bioinformatics come in here. It's more of like logic. Anyone can give any better examples and/or explain how it works to me. THanks.

They help in research, particularly in comparative terms.
Let's use your calcium channel example. By applying x-omics you can find similarly related genes and proteins using databases (e.g. BLAST search); direct analysis can predict of the structure (folding, conditions, active sites) of the gene and protein.

Finding related stuff is always a good place to start. Why work from scratch when you can build your research (or at least literally, search) on existing knowledge? E.g. If the calcium channel in the heart is similar to a channel say in the muscle, and there's already a lot of research on it, then you can try out the drugs that have been tested in the muscle. Don't for get cross-species examples; how do we relate our research from rats to humans? By identifying the most homologous structures in the other species.

November 19 2008 | Bioinformatics | 1 Comment »

What kind of classes should i take to prepare for Bioinformatics?

I am a sophmore in high school any suggestions in what classes i should take to get prepared for this field??

BTW: The school i attend is a very technology related schools

I am a Bioinformatics major from college. And I wish I had taken more computer science courses. The courses I had consisted of
C++ programming, database design. algorithms, basic bioinformatics (analytical tools), advanced bioinformatics, JAVA, php etc etc

Also basic biology and moelcular biology was a must while I took other courses such as genetics, neuroscience, evolution,. histology, immunology.

Then math was important. I had to take calculus 1 and 2, statistics.

So I’d take any class that would help these areas.

November 15 2008 | Bioinformatics | 3 Comments »

What kind of classes should i take to prepare for Bioinformatics?

I am a sophmore in high school any suggestions in what classes i should take to get prepared for this field??

BTW: The school i attend is a very technology related schools

I am a Bioinformatics major from college. And I wish I had taken more computer science courses. The courses I had consisted of
C++ programming, database design. algorithms, basic bioinformatics (analytical tools), advanced bioinformatics, JAVA, php etc etc

Also basic biology and moelcular biology was a must while I took other courses such as genetics, neuroscience, evolution,. histology, immunology.

Then math was important. I had to take calculus 1 and 2, statistics.

So I’d take any class that would help these areas.

November 15 2008 | Bioinformatics | 3 Comments »

What kind of classes should i take to prepare for Bioinformatics?

I am a sophmore in high school any suggestions in what classes i should take to get prepared for this field??

BTW: The school i attend is a very technology related schools

I am a Bioinformatics major from college. And I wish I had taken more computer science courses. The courses I had consisted of
C++ programming, database design. algorithms, basic bioinformatics (analytical tools), advanced bioinformatics, JAVA, php etc etc

Also basic biology and moelcular biology was a must while I took other courses such as genetics, neuroscience, evolution,. histology, immunology.

Then math was important. I had to take calculus 1 and 2, statistics.

So I’d take any class that would help these areas.

November 15 2008 | Bioinformatics | 3 Comments »

What kind of classes should i take to prepare for Bioinformatics?

I am a sophmore in high school any suggestions in what classes i should take to get prepared for this field??

BTW: The school i attend is a very technology related schools

I am a Bioinformatics major from college. And I wish I had taken more computer science courses. The courses I had consisted of
C++ programming, database design. algorithms, basic bioinformatics (analytical tools), advanced bioinformatics, JAVA, php etc etc

Also basic biology and moelcular biology was a must while I took other courses such as genetics, neuroscience, evolution,. histology, immunology.

Then math was important. I had to take calculus 1 and 2, statistics.

So I’d take any class that would help these areas.

November 15 2008 | Bioinformatics | 3 Comments »

Bioinformatics for Dummies

Bioinformatics for Dummies

Get “Bioinformatics for Dummies” new for only $20.61

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November 13 2008 | Bioinformatics | No Comments »

INTRO MACHINE LEARNING & BIOINFORMATICS BY MITRA

INTRO MACHINE LEARNING & BIOINFORMATICS BY MITRA

9781584886822 - SHEDS LIGHT ON ASPECTS OF BOTH MACHINE LEARNING & BIOINFORMATICS; SHOWS HOW INNOVATIVE TOOLS & TECHNIQUES OF MACHINE LEARNING HELP EXTRACT KNOWLEDGE FROM DELUGE OF INFORMATION PRODUCED BY TODAY’S BIOLOGICAL EXPERIMENTS.

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November 13 2008 | Bioinformatics | No Comments »

Introduction to Bioinformatics

Introduction to Bioinformatics

xvi+264p., Figures; Tables; Plates; 24cm.

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November 13 2008 | Bioinformatics | No Comments »

Seagate Drives Temasek Polytechnic’s Bioinformatics Laboratory

Seagate Drives Temasek Polytechnic's Bioinformatics Laboratory

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November 13 2008 | Bioinformatics | No Comments »

Bartholomew Frederick Dowling

Bartholomew Frederick Dowling

The purpose of this book is to introduce the field of bioinformatics to financial modelling. It focuses on the way information informs price, and constructs a framework to explain information generation and the agglomeration process, enabling the reader to make more effective financial decisions.

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November 13 2008 | Bioinformatics | No Comments »

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